In July 2021, ivermectin calls have continued to sharply increase, to a five-fold increase from baseline. received a three-fold increase in the number of calls for human exposures to ivermectin in January 2021 compared to the pre-pandemic baseline. In 2021, poison control centers across the U.S. Ivermectin dispensed by mail order and long-term care pharmacies, prescriptions by veterinarians, and non-oral formulations were not included. retail pharmacies, representing 92% of all retail prescription activity.
NPA Weekly collects data from a sample of approximately 48,900 U.S. *Data are from the IQVIA National Prescription Audit Weekly (NPA Weekly) database. ( Figure)įigure : Estimated number of outpatient ivermectin prescriptions dispensed from retail pharmacies - United States, March 16, 2019–August 13, 2021* This represents a 24-fold increase from the pre-pandemic baseline. 1 Since early July 2021, outpatient ivermectin dispensing has again begun to rapidly increase, reaching more than 88,000 prescriptions in the week ending August 13, 2021. Data from adequately sized, well-designed, and well-conducted clinical trials are needed to provide more specific, evidence-based guidance on the role of ivermectin in the treatment of COVID-19.Ī recent study examining trends in ivermectin dispensing from outpatient retail pharmacies in the United States during the COVID-19 pandemic showed an increase from an average of 3,600 prescriptions per week at the pre-pandemic baseline (March 16, 2019–March 13, 2020) to a peak of 39,000 prescriptions in the week ending on January 8, 2021. When used in appropriate doses for approved indications, ivermectin is generally well tolerated.Ĭlinical trials and observational studies to evaluate the use of ivermectin to prevent and treat COVID-19 in humans have yielded insufficient evidence for the NIH COVID-19 Treatment Guidelines Panel to recommend its use. Ivermectin is also used in veterinary applications to prevent or treat internal and external parasitic infections in animals. Topical formulations are used to treat head lice and rosacea. Ivermectin is a medication that is approved by FDA in oral formulations to treat onchocerciasis (river blindness) and intestinal strongyloidiasis. These reports include increased use of veterinary products not meant for human consumption. The Centers for Disease Control and Prevention (CDC) confirmed with the American Association of Poison Control Centers (AAPCC) that human exposures and adverse effects associated with ivermectin reported to poison control centers have increased in 2021 compared to the pre-pandemic baseline. external icon has listings of ongoing clinical trials that might provide more information about these hypothesized uses in the future.Īdverse effects associated with ivermectin misuse and overdose are increasing, as shown by a rise in calls to poison control centers reporting overdoses and more people experiencing adverse effects. The National Institutes of Health’s (NIH) COVID-19 Treatment Guidelines Panel has also determined that there are currently insufficient data to recommend ivermectin for treatment of COVID-19. Ivermectin is not authorized or approved by FDA for prevention or treatment of COVID-19. FDA has cautioned about the potential risks of use for prevention or treatment of COVID-19. When used as prescribed for approved indications, it is generally safe and well tolerated.ĭuring the COVID-19 pandemic, ivermectin dispensing by retail pharmacies has increased, as has use of veterinary formulations available over the counter but not intended for human use. Food and Drug Administration (FDA)-approved prescription medication used to treat certain infections caused by internal and external parasites. Distributed via the CDC Health Alert Network
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